- Baymont by Wyndham Florence
- Best Western Inn
- Comfort Suites Florence I-95
- Country Inn & Suites by Radisson, Florence, SC
- Courtyard by Marriott Florence
- Days Inn by Wyndham Florence/I-95 North
- Econo Lodge
- Florence Express Inn
- Florence Inn And Suites
- Hampton Inn & Suites Florence Center
- Hampton Inn & Suites Florence-North-I-95
- Hilton Garden Inn Florence
- Holiday Inn Ex Hotel & Suites Florence I-95 & I-20 Civic Ctr
- Holiday Inn Express & Suites Florence I-95 @ Hwy 327
- Home2 Suites by Hilton Florence
- Homewood Suites by Hilton Florence
- Hotel Florence, Tapestry Collection by Hilton
- Howard Johnson by Wyndham Florence
- Knights Inn Florence Sc
- La Quinta Inn & Suites by Wyndham Florence
- Microtel Inn & Suites by Wyndham Florence
- Motel 6 Florence, SC
- Quality Inn & Suites Civic Center
- Red Roof Inn Florence Civic Center
- Residence Inn Marriott Florence
- Sleep Inn Florence
- SpringHill Suites by Marriott Florence
- Staybridge Suites Florence - Civic Center
- Suburban Studios Florence I-95
- Super 8 by Wyndham Florence
- Super 8 by Wyndham Florence SC I-95 North - Hwy 76
- Tree Top Inn Florence